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The STEP 4 trial showed that people who stopped medication regained significant weight, while those who continued maintained their results

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Last reviewed: June 11, 2026 Last updated: June 11, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

However, introduce fiber gradually to avoid worsening bloating or gas, and ensure adequate fluid intake (at least 8 ounces of water with fiber supplements) to prevent worsening constipation