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Treatment of DIO mice with PYYMK-801 and GIPMK-801 did not affect body weight or food intake beyond that of the parent peptide analogues (Extended Data Fig

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Upon titration of UNC10088, the WT NSD2 protein exhibited a higher percent association with the FBXO22 FIST domain than any of the NSD2 variants tested (K253W, K253D, K253E) (Supplementary Fig

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Upon oxidative stress, sudden MPT causes massive ion influx that dissipates mitochondrial membrane potential and shuts down OXPHOS, ATP production and ROS overgeneration

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