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Metformin has been shown to decrease the synthesis of intestine-derived triglycerides-rich lipoproteins, which leads to a decrease in plasma concentrations of chylomicrons and chylomicron remnant lipoprotein fractions (Zhang et al., 2018)

The excess production of NADH during the catabolism of proline in the gdh3 / gdh3 mutant could be at the expense of NAD + supply and formation of the NADPH needed for cellular division and hyphal development

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