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Further understanding of the importance of ROS in normal physiological processes and rationally designed antioxidants that do not undermine normal physiology, but might be effective under pathological conditions, are both needed

Cell Death & Disease , 15 (7), 513 Chi, R., Yao, C., Chen, S., Liu, Y., He, Y., Zhang, J., Ellies, L

Supplementary Table S3-7 ), ratio of phosphorylated ERK 1/2 to the total ERK 1/2 ( Supplementary Figure S1-32 , Supplementary Table S3-7 ), phosphorylated JNK to total JNK ratio ( Supplementary Figure S1-33

SIRT1, localized in the nucleus, deacetylases and activates proliferator-activated receptor gamma coactivator-1 (PGC-1), which leads to increased mitochondrial biogenesis 103