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Science 291 (5504): 643-6

There is new evidence that does not support the American Society of Anesthesiologists recommendation

This biguanide derivate is the most widely prescribed drug to manage glucose metabolism in individuals with T2DM and is still recommended, in conjunction with lifestyle modification, as a first line medication in the joint guidelines of the American Diabetes Association and the European Association of the Study of Diabetes [1]

Higher tCr at 12 days was significantly associated with higher cognitive symptoms at 3 months (B = 2.095, p = 0.037, r = 0.097, Fig