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Born in 1923 in New York City shortly after her Greek family emigrated, Maria Anna Cecilia Sofa Kalogeropoulos received training in singing in Greece while a teen, then became famous for her bel canto style of singing (think of a broad, flexible voice and drama in how she interpreted the music) while in Italy
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The third wave began when powerful synthetic opioids like fentanyl started appearing in the supply around 2015
In yeast cells, exposure to copper leads to the degradation and internalization of CTR1, decreasing the cellular accumulation of cisplatin and increasing cisplatin resistance 73
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