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In humans, circulating E2 derives predominantly from aromatization in peripheral adipose tissues and 4060% of the total pool in women circulates bound to sex hormone-binding globulin SHBG circulation [80]

Key Takeaways Nicotine activates the cholinergic anti-inflammatory pathway (CAP) via the alpha-7 nicotinic acetylcholine receptor (7nAChR) reducing pro-inflammatory cytokines like TNF-, IL-1 and IL-6 This mechanism was first mapped by Dr Kevin Tracey in a landmark Nature paper (2002) and is one of the most cited discoveries in neuroimmunology Nicotine has been clinically tested for ulcerative colitis with evidence of benefit in active disease, particularly combined with mesalazine The anti-inflammatory effect of nicotine is overwhelmed by tobacco combustion smoking creates massive pro-inflammatory oxidative stress

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