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Either dysfunctions or hyperfunctions are implicated in a variety of disorders, particularly congenital sensory neuropathy, sensory neuropathy caused by diabetes, herpes zoster, postherpetic neuralgia, atopic dermatitis, impaired healing of injured tissue (e.g

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To overcome therapeutic resistance, targeting metabolic pathways, combination therapies, and the development of drugs aimed at the tumor microenvironment offer new hope