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Molecular intersections and distinctions between cuproptosis and other regulated cell-death pathways Copper homeostasis is a tightly regulated process that is essential for cardiovascular health and balances systemic absorption, distribution, utilization, and excretion
Two possible sites were identified in the catalytic subunit of glutamate-cysteine ligase (GCLC), the rate limiting enzyme for GSH synthesis
Prior evidence has indicated that GGCT plays a critical role in maintaining redox balance and prolonging lifespan in red blood cells via the regulation of GSH metabolism, providing a key clue for exploring the crosstalk between Gln and GGCT in cancer [31]
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