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The role of IGF-II should be viewed in the light of Efstradiadis series of knock-out experiments in mice (21) where the Igf2 ko mice had the same degree of fetal growth retardation as the igf1 ko which demonstrates that IGF-II is a paracrine/autocrine and not an endocrine hormone
Other glycolysis-related rate-limiting enzymes include, but are not limited to, PFKB3 and PKM2, which have garnered remarkable attention as potential anti-arthritis treatments (Wu et al., 2021)
Hursel, R, et al
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