However, in aged populations, the target cells in ORNs by cigarette smoke, the underlying molecular mechanisms by which cigarette smoke impairs the regenerative ORNs, and the degree of ORN regeneration after smoking cessation remain unclear
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Warnings and Precautions The cardiovascular effects of nicotine may be risky in patients with severe cardiovascular disease (peripheral occlusive arterial disease, cerebrovascular disease, unstable angina pectoris, and heart failure), vasospasms, uncontrolled hypertension, severe hepatic and/or renal insufficiency, and active duodenal and gastric ulcers