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While patients in this study had not previously been on TTh, the clinical application of this therapy for clinically symptomatic hypogonadal males who have ceased TTh in an effort to recover spermatogenesis remains an area of hopeful investigation

Despite its short duration, the current study had significant results in its composite endpoint, but did not significantly impact the physical activity (6-min walk test), QoL, and mTOR phosphorylation which may have improved with prolonged supplementation

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