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Pathological causes of elevated B12 warrant careful consideration: Haematological disorders : Myeloproliferative neoplasms (polycythaemia vera, chronic myeloid leukaemia), acute leukaemia, and lymphoproliferative disorders can increase B12-binding proteins (transcobalamin and haptocorrin), elevating total serum B12 [3] Liver disease : Hepatocellular damage releases stored B12 into circulation

doi: 10.1016/j.biopsych.2005.02.005

They would have different cohorts for each dose, plus a control group receiving only a saline injection, to isolate the effects of the peptide