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3 Los AR de GLP-1 llevan una advertencia en caja sobre posibles tumores de clulas C tiroideas basada en el aumento del riesgo de estos tumores en los estudios con ratas

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The measured outcome was the incidence of suicidal thoughts or attempts during the follow-up period of 12 months

Pathophysiological factors such as ischemia, hypoxia, oxidative stress, or calcium homeostasis disorders can disrupt endoplasmic reticulum homeostasis, cause endoplasmic reticulum dysfunction, and lead to the accumulation of unfolded or misfolded proteins, thus inducing ERS and triggering unfolded protein response, thereby activating the corresponding endoplasmic reticulum and calcium regulatory mechanisms and other signal transduction pathways to restore endoplasmic reticulum homeostasis