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Depletion of Methylfolate Directly Another way the body breaks the peroxynitrite cycle is by directly scavenging peroxynitrite using methylfolate.34 This results in oxidized methylfolate, which cannot be used until it has been regenerated back to its original form by ascorbic acid (vitamin C).36 This is another pathway that reduces folate levels, contributing to low thymidine levels and potential DNA strand breaks