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A bottle of bac water that has been sitting on a shelf for a few years might still look clear and fine, but the preservative inside might have lost some of its effectiveness

Preferably, take it first thing in the morning and before bed without food

If a nootropic asks you to cycle, or occasionally take a few days off from taking it, its likely that it contains ingredients that could build up in your system or that you could more easily develop a tolerance to over time