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L'encapsulation du Busulfan peut tre optimise en testant :The encapsulation of Busulfan can be optimized by testing: - Plusieurs cycles d'imprgnation - Diffrents temps d'imprgnation- Several impregnation cycles - Different impregnation times - Encapsulation par sublimation- Sublimation encapsulation - Utilisation de plusieurs solides avec un plus grand volume poreux (MIL-101 biphenyl, MIL88D modifie avec diffrents groupes organiques) et de solides hybrides avec des ligands modifis (NH2, Cl, NO2, COOH, CH3, etc) pour optimiser les interactions mdicament- solide

This leads to a need for increasing amounts of tobacco to achieve the same effect

n=452) of the 860 smokers started smoking when they were aged between 18 and 30 years, and this was significantly associated with male gender (p=0.028)