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Cigarette smoke induces COPD-related airway remodeling phenotypes, including airway epithelial hyperplasia, myocyte hyperplasia, squamous metaplasia, EMT, ciliary alterations, loss of secretory cells that produce Scgb1a1, and reduced integrity of the apical junction barrier that controls airway epithelial permeability

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In the study titled Association of Smoking and E-Cigarette in Chronic Liver Disease: An NHANES Study published in Gastroenterology Research claimed that e-cigarette users might have a higher risk of developing liver disease compared to non-smokers

[1] The World Health Organization (WHO) Framework Convention on Tobacco Control (FCTC) Article 13 implementation guidelines state that vending machines should be banned because, by their presence, they function as a form of tobacco advertising and promotion