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Tobacco-Related Disorders Are Distressing But Manageable The extensive use of tobacco is becoming the leading cause of death globally

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Increased levels of ROS contribute to inactivation of antiproteases (such as a1-antitrypsin) and activation of metalloproteases (MMPs), resulting in protease/antiprotease imbalance in the lungs, which directly contributes to the degradation of the lung matrix [94]

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