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Molecular Identity Developer Eli Lilly Brand Names Mounjaro (diabetes), Zepbound (obesity) Mechanism Dual GLP-1 and GIP receptor agonist FDA Status Approved (2022 diabetes, 2023 obesity) Administration Weekly subcutaneous GIP Receptor Pathway The GIP receptor activation in Tirzepatide provides different metabolic effects than glucagon: Incretin enhancement: GIP augments GLP-1's insulin-related signaling Adipose tissue effects: GIP receptor expression in fat tissue documented Tolerability profile: Some research suggests GIP may moderate GI effects Synergistic incretin signaling: Two incretin pathways vs

Fold change was calculated by dividing the metabolite concentration in each of the older age groups by the concentration in the 2-month-old group

doi: 10.1016/j.autrev.2012.01.005 101 Nunez-CruzSGimottyPAGuerraMWConnollyDCWuY-QDeAngelisRAet al

435, Nov