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Moderate-severe steatosis was evident from 12 weeks and all mice demonstrated advanced steatosis (score 3) from 24 to 36 weeks followed by a gradual decline in NAS explained by reduced steatosis score from 48 weeks and onwards (Figs

The three nitric oxide synthases (NOS)inducible NOS (iNOS), endothelial NOS (eNOS), and neuronal NOS (nNOS)interact with hydrogen sulfide (H 2 S) to regulate oxidative stress and tumor growth

The safety profile remains consistent with shorter term studies

The structure of this features a plasminogen (Kringle) (K) domain IV (KIV 1KIV 10), a Kringle domain V (KV), and an inactive protease domain (P)