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FIGURE 2 2 GLP-1R molecular imaging in insulinoma Even before the discovery of exendin-4, its homolog exendin-3 was successfully synthesized by 125I labeling and utilized in two models of insulinoma (NEDH rats and RINm 5F cells) (Gotthardt et al., 2002), which opened the chapter of GLP-1R imaging for 21 years

These in vitro experiments showed that cytokines and uremic toxins reduce RBC viability and trigger eryptosis in a time- and dose-dependent manner [256]

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