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The Nrf2-ARE signaling pathway activates and enhances the expression of downstream antioxidant enzymes, serving as a critical cellular defense mechanism against oxidative stress (236)

doi: 10.1126/scitranslmed.aav0936 Summary Keywords colorectal cancer, drug tolerance, ferroptosis, glutathione peroxidase 4 (GPX4), ferrous iron Citation Zhang X, Ma Y, Ma J, Yang L, Song Q, Wang H and Lv G (2022) Glutathione Peroxidase 4 as a Therapeutic Target for Anti-Colorectal Cancer Drug-Tolerant Persister Cells

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