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While women produce significantly less testosterone than men, the hormone is essential for maintaining muscle mass, bone density, mood regulation, and overall well-being

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(4) + Leucine and nicotinic acid works on the same mechanisms as caloric restriction and exercise to activate the SIRT/NAD+/AMPK axis to improve vasodilation, lower lipids, and decrease inflammation and foam cell production

Later work has built on that finding, including a 2023 peer-reviewed review on MOTS-Cs role in metabolic disorders