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Clinical features of DPN were assessed using the validated Modified Toronto Clinical Neuropathy Scale (mTCNS) [6] and Total Neuropathy Score (TNS) [4]

For the newer GLP-1 medications, it would be useful to look at whether there are genetic variants, like the variants in PAM, that explain poor responders to their medications. For now, the mechanism driving GLP-1 resistance remains unresolved, but it is likely complex and multifactorial, Gloyn said

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In order to determine if the differences in immunoreactivity were significant, the number of immunoreactive cells in the GCL and INL in rats from all three groups were recorded