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Pain flares can limit movement and influence appetite, especially when fatigue or nausea disrupts eating patterns

This connection to autism has been supported by a set of rare primary mitochondrial and nuclear genetic disorders that sometimes have autism as a clinical manifestation (48, 49)

Finally, we identified ACSL1, which has been shown to favor ferroptosis through the incorporation of PUFAs, especially conjugated linoleates, into triacylglycerols, favoring their oxidation after exceeding a certain PUFA level [48]

1 The COVID-19 pandemic increased the prevalence of overweight and obesity, primarily linked to quarantine measures, lockdowns, self-isolation, and decreased physical activity