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Zepbound is FDA-approved for chronic weight management in obesity (body mass index of 30 or more) or overweight (body mass index of 27 or more) with at least one weight-related condition (such as high blood pressure, type 2 diabetes or high cholesterol) in addition to a low-calorie diet and exercise

Back Baden, A (14 May 2025) 'People who stop weight loss drugs return to original weight within year, analysis finds', The Guardian

Most reported side effects (anecdotally) are: Mild GI discomfort, bloating, fatigue (primarily due to accelerated fat metabolism) and temporary injection site irritation

It means the comparison usually favors ipamorelin when selectivity is important