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A study using antibiotic treatment to deplete butyrate-producing microbes revealed that this type of dysbiosis supports Enterobacteriaceae expansion and inflammation through suppression of the peroxisome proliferator-activated receptor gamma (PPAR-) homeostatic signaling pathway [38]

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First approved to treat type 2 diabetes, GLP-1 based drugs are now used to aid weight loss in obesity and to help lower the risk of heart failure and treat obstructive sleep apnea, a common breathing-related sleep disorder, in people with obesity

Moreover, the beneficial effects of aFGF on Schwan cell behavior and abnormal myelin morphology were probably due to the inhibition of hyperglycemia-induced oxidative stress activation [145]