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The lining of your gut helps with digestion and over time, the lining can weaken and lead to leaky gut syndrome, says Zumpano

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Across the SURPASS phase 3 programme versus placebo and active comparators, including semaglutide, tirzepatide has shown superior dose-dependent reductions in HbA1c levels up to 2.5% and body weight up to 13%, compared with all comparators [88-91]

This paper extends our current knowledge of the effectiveness of this class of medications. Weighing benefits and risks The greatest risk increases were seen for nausea and vomiting, kidney stones, gastroesophageal reflux disease or GERD, sleep disturbances and non-infectious gastroenteritis, which is inflammation of the digestive tract which can cause nausea, vomiting, diarrhea and stomach cramps