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Severe Kidney or Liver Disease and Drug Interaction Risks Patients with eGFR below 15 mL/min/1.73m (Stage 5 chronic kidney disease) or those on dialysis may not be suitable candidates for tirzepatide, as limited pharmacokinetic data exists in end-stage renal disease

The role of SGLT2i in diabetic HFpEF SGLT2i, a class of the most recent anti-hyperglycemic drugs, have demonstrated beneficial effects on cardiovascular outcomes and played an important role in DM patients with HFpEF (Table 2)

The medication is compounded by licensed 503A pharmacies and is HSA/FSA eligible, making it accessible for most budgets

Figure 30: Photograph of Professor Sir Stephen Bloom, 2013, credit: Bloom