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Recent reviews indicate that suitably engineered CQDs can traverse the BBB via receptor-mediated endocytosis and adsorptive-mediated transcytosis, with surface charge and amphiphilicity influencing endothelial interactions and uptake efficiency, although the relative contributions of these pathways are not yet well defined [143]

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Minireview: Nuclear insulin and insulin-like growth factor-1 receptors: A novel paradigm in signal transduction