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In type 1 diabetes mellitus, DKD typically manifests as diabetic glomerulopathy, characterized by thickening of the glomerular basement membrane, mesangial matrix expansion, and hyalinosis affecting both afferent and efferent arterioles [21,22]

Beyond the established mechanisms, a pivotal contributor to DCM pathogenesis is the disruption of systemic and cellular copper homeostasis, which primarily inflicts damage through the aberrant compartmentalization of copper within cardiac tissues [80]

Cortisol, the stress hormone," plays a crucial role in the bodys response to stress

[DOI] [PubMed] [Google Scholar] 5.Jastreboff A.M., Aronne L.J., Ahmad N.N., Wharton S., Connery L., Alves B., et al