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23 With an increasing global demand for recreation and habitation at high altitudes, people, especially travelers, altitude residents, physicians, or paramedical personnel, need to be familiar with symptom recognition and the pathogenic mechanisms of high altitude-related sickness, so that appropriate and novel prevention and treatment methods can be adopted to reduce the severity or morbidity

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383 HAPE Ca 2+ antagonist: nifedipine Given that excessive HPV contributes to HAPE pathogenesis, the pulmonary vasodilator nifedipine stands out as the primary medication for HAPE prevention