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Allopurinol and oxypurinol are hydroxyl radical scavengers

Importantly, several studies indicate that these metabolites may retain partial biological activity, suggesting that in vivo effects attributed to HTY may arise from a combination of parent compound and metabolite-mediated mechanisms [56]

According to previous research ( in vitro , the levels of Tumor necrosis factor ligand superfamily member(TNF)-, IL-8, and IL-1 in the cell supernatant were greater than in the control group ( Inflammation and oxidative stress are interrelated, and increases in oxidative stress can cause acute and chronic inflammation ( 4.3 EMS influences GCs steroid hormone production The synthesis and secretion of steroid hormones by GCs is critical for follicular growth and, as a result, can impact the quality of oocytes

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