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Arthritis Rheumatol (2016) 68(11):272839

In a systematic review by Filippou et al., a mean reduction of 1.5 mmHg in both systolic and diastolic BP across 30 MedDiet intervention studies was estimated, an effect associated with a 20%25% reduction in major cardiovascular events [18], comparable to pharmacologic treatment benchmarks outlined in the Systolic Blood Pressure Intervention Trial (SPRINT) and Heart Outcomes Prevention Evaluation (HOPE) trials [19]

The psychological aspect of side effect perception deserves acknowledgment

10.1128/AEM.01475-06 [DOI] [PMC free article] [PubMed] [Google Scholar] Mart i Lndez A., Reith W