Pernicious anaemia is caused by a deficiency in vitamin B12, due to atrophic gastritis, an autoimmune condition (immune system destroys self), in this case the parietal cells of the stomach that produce intrinsic factor, a glycoprotein that binds to vitamin B12 in the stomach and is essential for normal absorption of vitamin B12 in the small intestine into the blood
Although high doses of B12 are generally considered safe due to its water-soluble nature, most individuals can obtain sufficient B12 through a balanced diet that includes foods like meat, eggs, and fortified cereals
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