From the doseinhibition curves established in vitro, circulating GLP-1(936) (~30 pmol/l) can be expected to inhibit glucagon secretion by up to 80%, making it difficult to observe any additional suppression by exogenous administration (especially under normoglycaemic conditions when glucagon secretion is already strongly reduced) (schematic Fig
During hypoxia, VEGF will be secreted from the pericytes which affects claudin-5 and BBB integrity via paracellular pathway ( Platelet-Derived Growth Factor (PDGF)-B/PDGF Receptor Beta (PDGFR) At early stages of vessel formation, tip ECs will secrete PDGF-B to promote the recruitment of pericyte progenitor cells
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The standard approach involves slowing dose escalation if side effects are severe, temporarily reducing the dose if a new tier causes significant discomfort, and providing dietary recommendations to minimize gastrointestinal symptoms
