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Accessed October 4, 2023

Study Enrollment Criteria To qualify for ORCA-3, participants must (be/have): Age 18 years Current daily cigarette smokers who smoke ten or more cigarettes per day and who intend to quit smoking Failed at least one previous attempt to stop smoking with or without therapeutic support Willing to set a quit date within 5-7 days of starting treatment Willing to actively participate in the studys smoking cessation behavioral support provided throughout the study Doctors will check other requirements to confirm that participants qualify for this study

The flow was diverted to waste until one minute before the expected nornicotine elution time so as not to introduce concentrated nicotine into the mass spectrometer

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