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As these recent studies show that higher oral doses of L-carnitine can promote atherogenesis and CVD risk, these findings also support our contention of limiting the oral maintenance dosing of L-carnitine to 3 g per day in the setting of acute MI and call for further investigation on the long-term risks of chronic L-carnitine supplementation in CVD patients

Within the mitochondria, lactate can be oxidized to pyruvate by a complex referred to as the mitochondrial lactate oxidation complex, mLOC