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The addition of GSH or expression of Grxs 1 and 2 significantly improves mutant SOD1 solubility in cell culture, whereas reducing the levels of intracellular GSH decreases SOD1 solubility, suggesting that GSH reduction promotes the aggregation of mutant SOD1 (Guareschi et al., 2012)

Emptying of solids exhibits a lag phase followed by a prolonged linear emptying phase [71]

The gutbrain axis, a bidirectional communication network involving the vagus nerve, enteric nervous system, and hypothalamic-pituitary-adrenal (HPA) axis, may influence cognitive and mood symptoms

Thus, the rarity of perioperative pulmonary aspiration is an important limitation in our cohort of 426 patients, of whom 81 received no sedation, leaving only 345 in actual risk of perioperative pulmonary aspiration