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It was also proved that matrix-detached epithelial and cancer cells cluster spontaneously through a pathway involved with Nectin-4 (also known as cell adhesion protein PVRL4), the process of which sustains GPX4 expression and buffers against lipid peroxidation by stimulating the PVRL4/64/Src axis signal pathway (Brown et al., 2018)

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Copper deficiency reduced the life span of rats by 73%, and Viestenz and Klevay (117) also reported that dietary copper deficiency led to ECG abnormalities in rats

Both reduced folate carrier and proton-coupled folate transporter are the most common ways used by folates to reach tissues