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Adherence differences between daily and weekly dosing likely contribute to real-world efficacy differences as well

Regular treatments, particularly IV infusions or injections, can help reduce dark spots, promote an even skin tone, and improve overall skin radiance

However, many people experience dramatic improvement or near-complete resolution of symptoms by addressing root causes: healing gut inflammation to restore DAO production 24 , supporting methylation for HNMT function, stabilizing mast cells, and identifying personal triggers

Early in vivo studies in humans showed no effect of somatostatin on basal or CRH-stimulated ACTH release (130), although somatostatin does decrease basal secretion in the context of Addisons disease (131)