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In case of breast cancer lacking PTEN , PI3KB expression in cancerous cells alters the CD4+ and CD8+ T-cell infiltration via the BMX/STAT3 signaling pathway, facilitating the immune desert formation within tumors and promoting tumor immune evasiveness (152)

When T cells are continuously stimulated, mitochondrial function is inhibited, impairing TCA cycling and oxidative phosphorylation

11 (6), 561570 (2010) J

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