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Compared to the placebo group, patients who took 3 g of immediate-release nicotinic acid daily experienced an average 10% reduction in total blood cholesterol, a 26% decrease in triglycerides, a 27% reduction in recurrent nonfatal myocardial infarction, and a 26% reduction in cerebrovascular events (stroke and transient ischemic attacks)

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Through synthetic biology techniques, probiotics are modified to enable targeted release of therapeutic molecules in the gut, enhancing anti-inflammatory effects and improving colonization ability [415, 421, 422]