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1 However, doctors sometimes prescribe it off-label for weight management due to its appetite-suppressing effects
For example, females had a higher risk of anxiety (2.19, 95% CI: 2.142.24) and suicidal ideations or attempts (2.53, 95% CI: 2.322.76) compared to males
Sertraline is processed primarily by cytochrome P450 enzymes in the liver, particularly CYP2B6, CYP2C19, and CYP3A4 Because they dont share metabolic pathways, theres no competition for the same enzymes and therefore no direct drug-drug interaction
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