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Low-quality studies typically had issues in their methodology, such as unclear or inadequate management of confounding factors, unreliable or invalid outcome measurements, incomplete follow-up without adequate exploration of reasons, and inappropriate or unclear use of statistical analysis

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Computed tomographic scans of the head, chest and abdomen were negative for metastatic disease

Weight loss typically becomes measurable after four to six weeks of consistent dosing, allowing enough time for the medication to build steady blood levels and for your body to adapt to reduced caloric intake