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The main inflammatory mediator is histamine, responsible for the sudden outbreak of swollen bumps or plaques on the skin (161), and a similar role is played by PGD2

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Saxenda (active ingredient: liraglutide) subcutaneous injection Initial FDA Approval: 2014 (liraglutide approved in 2010) Side Effect Update Date: May 28, 2025 Medication Description: For chronic weight management Updated Side Effects/Safety Information: A new warning section on Severe Gastrointestinal Adverse Reactions. An additional warning about the risk of serious kidney injury caused by dehydration due to gastrointestinal adverse effects like diarrhea and vomiting

Metabolism 65(8):10381048 Caballera L, Pera G, Rodrguez L, Auladell MA, Bernad J, Canut S, Toran P (2012) Metabolic syndrome and nonalcoholic fatty liver disease in a Spanish population: influence of the diagnostic criteria used