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Obesity and malnutrition [4], along with controllable lifestyle choices such as smoking, alcohol, and recreational drug use [7] have been linked to oxidative disturbances

Although upregulated glycolysis can temporarily support cell survival, the resultant accumulation of lactate and H+ alters local pH, undermines cartilage matrix homeostasis, and influences both amino acid and lipid metabolic pathways (101)

So, vitamin C provided considerable protection against uropathogenic adhesion and colonization of microbes that infect the urinary tract [17] through a high vitamin C consumption that tends to raise urine acidity, which is not well tolerated by the bacteria that cause UTIs [18]

It was found that DSIP significantly reduced pain levels in 6 out of 7 patients and was also able to significantly reduce depressive states