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In addition, dysregulated -KG flux from normal reductive anabolism via the TCA cycle toward R-2-HG production has been associated with other metabolic flux impairments and disrupted redox balance 119,120 (Fig

Moreover, in our recent study we also demonstrated that repeated administration of the BSO + GBR 12909 to 16-day-old rats induced a significant reduction in the level of lipid peroxidation in the frontal cortex and hippocampus, indicating a weakening of the oxidative power of their cells and ultimately leading to changes in redox cell signaling in the frontal cortex and hippocampus (40)