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Berberine combined with atorvastatin has been suggested to downregulate LOX-1 expression via ET-1 receptors in mono-cytes/macrophages ( 5.2.2 ABCA1/G1 ABCA1/G1 is an important macrophage receptor that promotes intracellular cholesterol efflux and reduces the formation of macrophage foam cells

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More water will produce more lather